Hereditary transthyretin amyloidosis, or hATTR, is a rare genetic disorder caused by the mis-folding and build-up of the transthyretin protein. Patients with this disorder present with a variety of clinical conditions including cardiomyopathy, neuropathy, and GI symptoms. When counseling a patient with hATTR, genetic counselors need to take a detailed family history and know what questions to ask to cover this vast range of symptoms.
On-Demand Education Modules
This education provides 4 patient cases to demonstrate the variety of patients with TTR amyloidosis genetic counselors may see. Discussions between expert physicians and specialized genetic counselors bring these patient cases to life in this interactive activity. Resources for genetic counselors and their patients are also available.
Live Webcast
Did you complete the free CEU course on this topic? Questions submitted by learners were answered in a live webcast. View the Recording.
Learning Objectives
Upon completion of the activity, participants should be able to:
- Review the pathology and epidemiology of ATTR and its manifestations
- Discuss the diagnostic and classification process for amyloidosis
- Differentiate between hATTR and ATTRwt based on genetic testing
- Identify hATTR mutations based on genetic testing results
- Summarize available and emerging treatment options for hATTR
- Review the presently available options for patient education
Faculty
Emily Brown, MGC, CGC
Certified Genetic Counselor
Center for Inherited Heart Disease
Johns Hopkins Hospital
Shawna Feely, MS, LGC
Licensed Genetic Counselor
Department of Neurology
University of Iowa
Mathew S. Maurer, MD
Professor of Medicine
Department of Medicine
Division of Cardiology
Arnold and Arlene Goldstein Professor of Cardiology
Medical Director, Clinical Cardiovascular Research Laboratory for the Elderly (CCRLE)
Columbia University
Michael E. Shy, MD
Director, Division of Neuromuscular Medicine
Professor of Neurology, Pediatrics and Molecular Physiology and Biophysics
Carver College of Medicine
University of Iowa
On-Demand Modules
Module 1: Introduction to TTR Amyloidosis
Dr. Mathew Maurer and Emily Brown
Module 2: ATTR-Cardiomyopathy: Wild Type vs. Hereditary Cases
Dr. Mathew Maurer and Emily Brown
Module 3: hATTR-Neuropathy: Introduction and Case Example
Dr. Michael Shy and Shawna Feely
Module 4: hATTR: A Case With a Mixed Phenotype
Dr. Michael Shy and Shawna Feely
Purchase Information
This activity is provided by the National Society of Genetic Counselors in collaboration with The France Foundation. It is available at no cost to genetic counselors. This activity is supported by educational grants from Akcea Therapeutics, Alnylam, and Pfizer. Register for the live webcast to be held on August 3. Add this complimentary course to your cart, then complete the free checkout process to gain access to this course.
Continuing Education
Accreditation Statement
The France Foundation is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Genetic Counselors
The National Society of Genetic Counselors (NSGC) has authorized The France Foundation to offer up to 0.1 CEUs or 1 Category 1 contact hours for the activity Hereditary Amyloid Transthyretin Amyloidosis: Recognizing the Needle in a Genetic Haystack. The American Board of Genetic Counseling (ABGC) will accept CEUs earned at this program for the purposes of genetic counselor certification and recertification.
Physicians
The France Foundation designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurses
Nurses who are certified by the American Nurses Credentialing Center (ANCC) may utilize activities that are certified by ACCME-accredited providers toward their requirement for certification renewal by the ANCC. A certificate of attendance will be provided by The France Foundation, an ACCME accredited provider.